CURRICULUM VITAE
Name: Ilker Tinay, M.D. Prof.
Office Address: Anadolu Medical Center
Department of Urooncology Department
Professor of Urology
Division of Urological Oncology
Executive Board Member
Association of Urooncology, Turkey
Secretary of the Bladder Tumors Research Group
Association of Urooncology, Turkey
Medical License Number : 114904
email: ilker.tinay@anadolusaglik.org
WORK EXPERIENCE:
February 2020- Anadolu Medical Center Department of Urology/Uro-oncology
October 2017 – 2020 Associate Professor of Urology Marmara University School of Medicine
April 2014 – October 2017 Assistant Professor of Urology Marmara University School of Medicine
November 2011 – April 2014 University Lecturer Marmara University School of Medicine
March 2010 – June 2011 Urologist Kurtalan State Hospital, Siirt, TURKEY
March 2009 – March 2010 Urologist Balikesir Military Hospital, TURKEY
EDUCATION:
1997-2003 Istanbul Faculty of Medicine, Istanbul University, Turkey
July – August 2000 General Surgery and Colorectal Surgery Clerkship Cleveland Clinic Foundation, Cleveland, U.S.A
July – August 1999 Basic and Clinic Microbiology Clerkship Oslo University Hospital, Ulleval, Norway
PROFESSIONAL SUMMARY:
❖ Physician-scientist with in-depth urological oncology experience in both clinical
practice and academia
Areas of Expertise:
• Deep understanding and experience with liquid biomarkers, namely microRNA in
• Rich experience in academic urological oncology, publishing, teaching and
invited speaker experiences
• Urological oncology clinical Phase 3 trial experience
prostate and urothelial carcinoma
• Minimal invasive and open tumor surgery with particular expertise;
in prostate cancer
in kidney cancer
urothelial carcinoma of the bladder and upper urinary tract
retroperitoneal post-chemotherapy resection (RPLND) germ cell tumors
• Urological oncology opinion leader in Turkey
Institutional Memberships
Executive Board Member Association of Urooncology
Secretary of the Bladder Tumors Research Group Association of Urooncology
Member Of Board Of Directors Of Urological Surgery Association, Northern Marmara Branch
Internatıonal Bladder Cancer Network
European Assocıatıon Of Urology Member
Member of the Amerıcan College Of Surgeons
Awards
Marmara University, Faculty of Medicine, Science Encouragement Award for Residency Students, 2008
National Urological Surgery Congress, Young Academic Presentation Award,2012
Urooncology Association Scientific Research Award, 2019
Publications
https://pubmed.ncbi.nlm.nih.gov/?term=tinay+i&sort=date
INTERNATIONAL PEER REVIEWED PUBLICATIONS
1. Kidney loss due to periureteral fibrosis and ureteral obstruction secondary to
migration of subureterically injected calcium hydroxylapatite. Önol FF, Tarcan T, Tinay
I, Kotiloğlu E, Şimşek F. Journal of Pediatric Urology, 2006; 2 (5): 503-508
2. Long-term results of endoscopic treatment of vesicoureteral reflux with the subureteric injection of calcium hydroxyapatite. Tarcan T, Tinay I, Temiz Y, Simşek F.
International Urology and Nephrology 2007; 39(4): 1011-1014
3. A new suture technique for anastomosis in radical retropubic prostatectomy and
early removal of urethral catheter. Türkeri L, Temiz Y, Yazıcı CM, Tinay I. The
Canadian Journal of Urology 2007; 14(6): 3697-3701
4. Erectile dysfunction following Radiotherapy and Brachytherapy for prostate cancer.
Akbal C, Tinay I, Şimşek F, Turkeri L. International Urology and Nephrology 2008;
40(2): 355-63
5. Advances in the Understanding of the Early Detection of Bladder Cancer. Turkeri L
and Tinay I. European Urological Review 2008; 3(2): 28-30
6. Outcome of preemptive penile rehabilitation before bilateral cavernosal nerve
injury in rats. Tavukcu HH, Akbal C, Tinay I, Simsek F, Turkeri L. World Journal of
Urology 2010; 28(6): 735-40
7. Recent Developments in Research and Treatment of Testicular Cancer: Highlights
from Oncologic Congresses in 2009. Tinay I and Turkeri L. European Urology
Supplements 2010; 9(3): 462-466
8. The value of sacral skin lesions in predicting occult spinal dysraphism in children
with voiding dysfunction and normal neurological examination. Tarcan T, Tinay I, Temiz
Y, Alpay H, Ozek M, Simsek F. J Pediatr Urol. 2012; 8(1): 55-58
9. Intradetrusor botulinum neurotoxin A (BoNT-A) injections decrease bladder fibrosis
secondary to partial urethral obstruction in the male rat model. Tinay I, Tanidir Y, Cikler
E, Cetinel S, Tarcan T. Neurourol Urodyn. 2012; 31(4): 564-70
10. Beneficial effects of quercetin on rat urinary bladder after spinal cord injury. Cevik
O, Ersahin M, Sener TE, Tinay I, Tarcan T, Cetinel S, Sener A, Toklu HZ and Sener G.
Journal of Surgical Research, 2013
11. An Alternative for Short Renal Vein during Kidney Transplantation: Long-term
Experience with Polyethylene Terephthalate (Dacron) Vascular Graft. Tinay I, Temiz Y,
Ilker Y, Tuglular S and Turkeri L. Urology 2013; 82(1): 245-7
12. Quercetin treatment against ischemia/reperfusion injury in rat corpus cavernosum
tissue: role on apoptosis and oxidative stress. Cevik O, Cadırcı S, Sener TE, Tınay I,
Akbal C, Tavukçu HH, Cetinel S, Kıran D, Sener G. Free Radic Res. 2013; 47(9): 683-
91
13. Diagnostic value of the pediatric lower urinary tract symptom score in children with
overactive bladder. Akbal C, Sahan A, Sener TE, Sahin B, Tinay I, Tarcan T, Simşek F.
World Journal of Urology 2014; 32(1): 201-8
14. Melatonin and tadalafil treatment improves erectile dysfunction after spinal cord
injury in rats. Tavukçu HH, Sener TE, Tinay I, Akbal C, Erşahin M, Cevik O, Cadırcı S,
Reiter RJ, Sener G. Clinical and Experimental Pharmacology and Physiology 2014;
41(4): 309-16
15. High rate of sexual dysfunction following surgery for rectal cancer. Attaallah W,
Ertekin C, Tinay I, Yegen C. Annals Coloproctology 2014; 30(5): 210-5
16. Significance of the interval between first and second transurethral resection on
recurrence and progression rates in patients with high-risk non-muscle-invasive bladder
cancer treated with maintenance intravesical Bacillus Calmette-Guérin. Baltacı S, Bozlu
M, Yıldırım A, Gökçe Mİ, Tinay I, Aslan G, Can C, Türkeri L, Kuyumcuoğlu U, Mungan
A. BJU Int. 2015 Nov;116(5):721-6
17. Association of BK Virus Titers With Lymphocyte Count in Renal Transplant
Patients. Velioglu A, Aksu B, Asicioglu E, Arıkan H, Tinay I, Yardimci S, Yegen C,
Tuglular S, Ozener C. Transplant Proc. 2015 Jun;47(5):1421-4
18. Contemporary trends in high-dose interleukin-2 use for metastatic renal cell
carcinoma in the United States. Allard CB, Gelpi-Hammerschmidt F, Harshman LC,
Choueiri TK, Faiena I, Modi P, Chung BI, Tinay I, Singer EA, Chang SL. Urol Oncol.
2015 Nov;33(11):496.e11-6
10
19. The Contemporary Incidence and Sequelae of Rhabdomyolysis Following
Extirpative Renal Surgery: A Population Based Analysis. Gelpi-Hammerschmidt F,
Tinay I, Allard CB, Su LM, Preston MA, Trinh QD, Kibel AS, Wang Y, Chung BI, Chang
SL. J Urol. 2016 Feb;195(2):399-405
20. Trends in utilization, perioperative outcomes and costs for nephroureterectomies in
the management of upper tract urothelial carcinoma (UTUC): a 10-year populationbased analysis. Tinay I, Gelpi-Hammerschmidt F, Leow JJ, Allard CB, Rodriguez D,
Wang Y, Chung BI, Chang SL. BJU International (2015), Doi: 10.1111/bju
21. Antioxidant Agent Quercetin Prevents Impairment of Bladder Tissue Contractility
and Apoptosis in a Rat Model of Ischemia/Reperfusion Injury. TINAY I, SENER TE,
ÇEVIK Ö, CADIRCI S, TOKLU H, ÇETINEL S, SENER G, TARCAN T. LUTS: Lower
Urinary Tract Symptoms (2015), Doi: 10.1111/luts.12125
22. Secretory leukocyte protease inhibitor is a survival and proliferation factor for
castration resistant prostate cancer. Zheng D, Gui B, Gray KP, Tinay I, Rafiei S, Huang
Q, Sweeney CJ, Kibel AS, Jia L. Oncogene (2016), Doi: 10.1038/onc.2016.13
23. Is 40?cm?H2O detrusor leak point pressure cut-off reliable for upper urinary tract
protection in children with myelodysplasia? Tarcan T, Sekerci ÇA, Akbal C, Tinay I,
Tanıdır Y, Sahan A, Sahin B, Top T, Simsek F. Neurourology and Urodynamics (2016),
Doi: 10.1002/nau.23017
24. Differentiation of ureteral stones and phleboliths using Hounsfield units on
computerized tomography: a new method without observer bias. Tanidir Y, Sahan A,
Asutay MK, Sener TE, Talibzade F, Garayev A, Tinay I, Sekerci CA, Simsek F.
Urolithiasis. 2017 Jun;45(3):323-328
25. The effect of doxazosin and sildenafil citrate combination on bladder tissue
contractility, alpha adrenergic receptor, and iNOS subtype expression in a male rat
model of partially bladder outlet obstruction. Gumrah A, Tanidir Y, Tinay I, Ozyurek M,
Tarcan T. Neurourol Urodyn. 2017 Aug;36(6):1479-1487
11
26. The effect of intradetrusor botulinum neurotoxin type A on urinary NGF, TGF BETA1, TIMP-2 levels in children with neurogenic detrusor overactivity due to
myelodysplasia. Top T, Sekerci CA, Isbilen-Basok B, Tanidir Y, Tinay I, Isman FK,
Akbal C, Simsek F, Tarcan T. Neurourol Urodyn. 2017 Sep;36(7):1896-1902
27. Androgen receptor-regulated miRNA-193a-3p targets AJUBA to promote prostate
cancer cell migration. Jia L, Gui B, Zheng D, Decker KF, Tinay I, Tan M, Wang X, Kibel
AS. Prostate. 2017 Jun;77(9):1000-1011.
28. Full blown nephrotic syndrome due to unilateral obstruction of the uretero-pelvic
junction. Atas DB, Arikan H, Tinay I, Asicioglu E, Velioglu A, Koc M, Tuglular S, Ozener
C. Nephrology (Carlton). 2017 Jun;22(6):498
29. Clinical Case Discussion: Bilateral Synchronous Testicular Cancer and Organsparing Surgery. Sener TE, Ozveren B, Tinay I, Cam K, Turkeri L. Eur Urol Focus. 2016
Aug 23. pii: S2405-4569(16)30111-0. doi: 10.1016/j.euf.2016.08.003
30.Jia L, Gui B, Zheng D, Decker KF, Tinay I, Tan M, Wang X, Kibel AS. Androgen
receptor-regulated miRNA-193a-3p targets AJUBA to promote prostate cancer
cell migration. Prostate. 2017 Jun;77(9):1000-1011. doi: 10.1002/pros.23356
31.Sener TE, Ozveren B, Tinay I, Cam K, Turkeri L. Clinical Case Discussion:
Bilateral Synchronous Testicular Cancer and Organ-sparing Surgery. Eur Urol
Focus. 2016 Aug 23. pii:S2405-4569(16)30111-0. doi:10.1016/j.euf.2016.08.003
32. Tinay I, Aslan G, Kural AR, Özen H, Akdoğan B, Yıldırım A, Ongün Ş, Özkan
A,Esen T, Zorlu F, Dillioğlugil Ö, Bekiroglu N, Türkeri L; Members of Urooncology
Association. Pathologic Outcomes of Candidates for Active Surveillance
Undergoing Radical Prostatectomy: Results from a Contemporary Turkish
Patient Cohort. Urol Int. 2018;100(1):43-49. doi: 10.1159/000481266
12
33. Tinay I, Tan M, Gui B, Werner L, Kibel AS, Jia L. Functional roles and potential
clinical application of miRNA-345-5p in prostate cancer. Prostate. 2018
Sep;78(12):927-937. doi: 10.1002/pros.23650
34. Sener TE, Tavukcu HH, Atasoy BM, Cevik O, Kaya OT, Cetinel S, Dagli Degerli
A,Tinay I, Simsek F, Akbal C, Butticè S, Sener G. Resveratrol treatment may
preserve the erectile function after radiotherapy by restoring antioxidant defence
mechanisms, SIRT1 and NOS protein expressions. Int J Impot Res. 2018
Aug;30(4):179-188. doi: 10.1038/s41443-018-0042-6
35. Amuran GG, Eyuboglu IP, Tinay I, Akkiprik M. New Insights in Bladder Cancer
Diagnosis: Urinary miRNAs and Proteins. Med Sci (Basel). 2018 Dec 7;6(4). pii:
E113. doi: 10.3390/medsci6040113. Review. PubMed PMID: 30544619; PubMed
Central PMCID: PMC6318758.
36. Guran T, Yesil G, Turan S, Atay Z, Bozkurtlar E, Aghayev A, Gul S, Tinay I, Aru
B, Arslan S, Koroglu MK, Ercan F, Demirel GY, Eren FS, Karademir B, Bereket
A. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and
impaired spermatogenesis in humans. Eur J Endocrinol. 2019 May 1;180(5):291-
309. doi: 10.1530/EJE-19-0067. PubMed PMID: 30893644.
37. Baykan O, Akgul M, Uren N, Yaman A, Tinay I, Ergul E, Sazci A, Turkeri L,
Haklar G. The Relationship Between Urothelial Type Bladder Cancer, Plasma
25-Hydroxyvitamin D Levels, and Vitamin D Receptor ApaI BsmI FokI, and TaqI
Polymorphisms. Clin Lab. 2019 Apr 1;65(4). doi: 10.7754/Clin.Lab.2018.180339.
PubMed PMID: 30969078.
38. Mehdiyev S, Velioglu A, Arikan H, Asicioglu E, Cincin A, Demirbas T, Tinay I,
Ozener C, Tuglular S. Cardiac Risk Assessment in Kidney Transplant
Candidates: Clinical Usefulness of Different Guidelines. Transplant Proc. 2019
May;51(4):1058-1063. doi: 10.1016/j.transproceed.2019.01.101. Epub 2019 Feb
8. PubMed PMID: 31101171.
13
39. Kanar BG, Ozben B, Sunbul M, Şener E, Ozkan O, Tınay I, Tigen MK.
Androgen-deprivation therapy impairs left ventricle functions in prostate cancer
patients. Int Urol Nephrol. 2019 Jul;51(7):1107-1112. doi: 10.1007/s11255-019-
02184-4. Epub 2019 Jun 4. PubMed PMID: 31165396.
40. Inanir S, Kesim S, Ergelen R, Tınay İ, Türköz HK. 68Ga-PSMA PET/CT in
Giant Retroperitoneal Liposarcoma. Clin Nucl Med. 2019 Nov;44(11):e612-e613.
doi: 10.1097/RLU.0000000000002762. PubMed PMID: 31524684.
41. Güllü Amuran G, Tinay I, Filinte D, Ilgin C, Peker Eyüboğlu I, Akkiprik M.
Urinary micro-RNA expressions and protein concentrations may differentiate
bladder cancer patients from healthy controls. Int Urol Nephrol. 2019 Nov 2. doi:
10.1007/s11255-019-02328-6. [Epub ahead of print] PubMed PMID: 31679136.
42. Nazım C Demircan 1, Özkan Alan 1, Tuğba Başoğlu Tüylü 1, Tuğba AkınTelli 1, Rukiye Arıkan 1, Furkan C Çiçek 2, Özlem Ercelep 1, Mehmet A Öztürk 3, İlknur Alsan Çetin 4, Rabia Ergelen 5, İlker Tinay 6, Nalan Akgül Babacan 1, Serap Kaya 1, Faysal Dane 1, Perran F Yumuk 1. Impact of the
Charlson Comorbidity Index on Dose-Limiting Toxicity and Survival in Locally
Advanced and Metastatic Renal Cell Carcinoma Patients Treated With First-Line
Sunitinib or Pazopanib [published online ahead of print, 2019 Dec 2]. J Oncol
Pharm Pract. 2019;1078155219890032. doi:10.1177/1078155219890032
43.The Early Impact of COVID-19 Pandemic on Surgical Urologic Oncology Practice
in Turkey: Multi-Institutional Experience From Different Geographic Areas.
Tinay I, Ozden E, Suer E, Bozkurt O, Izol V, Sahin B, Turkeri L.Urology. 2020
Aug;142:29-31
44. Hyperbaric oxygen therapy prevents subarachnoid hemorrhage-induced apoptosis
and impaired contractility of the rabbit bladder.
Tinay I, Celik O, Sekerci CA, Cadirci S, Cevik O, Oroglu B, Sener G, Tarcan
T.Neurourol Urodyn. 2020 Jun;39(5):1276-1282
44.Re: Marc-Oliver Grimm, Antione G. van der Heijden, Marc Colombel, et al. Nonmuscle-invasive Bladder Carcinoma by Standard Number and Dose of BCG
Instillations Versus Reduced Number and Standard Dose of BCG Instillations:
Results of the European Association of Urology Research Foundation
Randomised Phase III Clinical Trial “NIMBUS”. Eur Urol. In press.
https://doi.org/10.1016/j.eururo.2020.04.066.
Karabay E, Tınay İ.Eur Urol. 2020 Oct;78(4):e161-e162
45.The impact of tumor invasion to muscularis mucosaevascular plexus on patient
outcome in pT1 bladder urothelial carcinoma.
Sahan A, Gerin F, Garayev A, Bozkurtlar E, Çubuk A, Ozkaptan O, Ertas K,
Tanıdır Y, Cam HK, Tınay I.Arch Ital Urol Androl. 2020 Oct 2;92(3)
46.The Effect of Diagnostic Ureterorenoscopy on Intravesical Recurrence in Patients
Undergoing Nephroureterectomy for Primary Upper Tract Urinary Carcinoma.
İzol V, Deger M, Ozden E, Bolat D, Argun B, Baltaci S, Celik O, Akgul HM, Tinay
İ, Bayazit Y; Bladder Cancer Study Group of Association of Urooncology,
Turkey.Urol Int. 2020 Dec 2:1-7
47. Ta grade 3/high grade non-invasive bladder cancer: Should we perform a second TUR?
Tinay I, Baltaci S, Demirdag C, Akdogan B, Yucetas U, Simsekoglu MF, Haberal HB,
Bozlu M, Izol V, Aslan G, Bekiroğlu N; Bladder Cancer Study Group of Urooncology
Association, Turkey.Int J Clin Pract. 2020 Dec 10:e13924
